rs28942089
A SNP in the WT1 gene on chromosome 11. Its most notable genotype is A;G: Denys-Drash syndrome
- Gene
- WT1
- Location
- Chr 1132,392,672 (GRCh38)
- Highest magnitude
- 9.0Very important
- Tested on
- 23andMe, AncestryDNA
Genotypes
Plus strand, as in 23andMe and AncestryDNA files.
- G;GGoodcommon in clinvar
- A;GMost notableBadDenys-Drash syndrome
SNPedia records rs28942089 on the minus strand: (C;C), (C;T). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.
Related
Other WT1 SNPs
- rs28941778C;TDenys-Drash syndromeVery important
- rs28941779A;GFrasier syndrome mutationVery important
- rs121907900A;GWilms tumor susceptibility (predicted)Very important
- rs121907906A;GWilms tumor susceptibility (predicted)Very important
- rs121907908C;TWilms tumor susceptibility (predicted)Very important
- rs121907909A;GWilms tumor susceptibility (predicted)Very important
- rs121907911G;TWilms tumor susceptibility (predicted)Very important
- rs587776573-;ATTTATACCAAATGACAWilms tumor susceptibility (predicted)Very important
Notes
From SNPedia
Notes
rs28942089, also known as His377Tyr or H377Y, is a SNP in the WT1 gene on chromosome 11. The mutant allele for this SNP is considered causal for Denys-Drash syndrome, based on several reports. See also OMIM 607102.0012 This variant meets the criteria published in 2013 by the ACMG regarding incidental findings in exome or genome sequencing, as a variant that they do recommend informing a patient about.
A;G
see discussion at rs28942089
Source and license
Adapted from rs28942089 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.
SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.