rs28941779
A SNP in the WT1 gene on chromosome 11. Its most notable genotype is A;G: Frasier syndrome mutation
- Gene
- WT1
- Location
- Chr 1132,392,026 (GRCh38)
- Highest magnitude
- 9.0Very important
- Tested on
- 23andMe, AncestryDNA
Genotypes
Plus strand, as in 23andMe and AncestryDNA files.
SNPedia records rs28941779 on the minus strand: (C;T), (T;T). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.
Related
Other WT1 SNPs
- rs28941778C;TDenys-Drash syndromeVery important
- rs28942089A;GDenys-Drash syndromeVery important
- rs121907900A;GWilms tumor susceptibility (predicted)Very important
- rs121907906A;GWilms tumor susceptibility (predicted)Very important
- rs121907908C;TWilms tumor susceptibility (predicted)Very important
- rs121907909A;GWilms tumor susceptibility (predicted)Very important
- rs121907911G;TWilms tumor susceptibility (predicted)Very important
- rs587776573-;ATTTATACCAAATGACAWilms tumor susceptibility (predicted)Very important
Notes
From SNPedia
Notes
rs28941779, also known as Phe392Leu or F392L, is a SNP in the WT1 gene on chromosome 11. A report links a mutation at this SNP to the rare disease known as Frasier syndrome, which has similarities to Denys-Drash syndrome, no doubt in part since both are based on mutations in the WT1 gene. See also OMIM 607102.0025 This variant meets the criteria published in 2013 by the ACMG regarding incidental findings in exome or genome sequencing, as a variant that they do recommend informing a patient about.
A;G
see discussion at rs28941779
Source and license
Adapted from rs28941779 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.
SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.