rs28941778
A SNP in the WT1 gene on chromosome 11. Its most notable genotype is C;T: Denys-Drash syndrome
- Gene
- WT1
- Location
- Chr 1132,392,014 (GRCh38)
- Highest magnitude
- 9.0Very important
- Tested on
- 23andMe, AncestryDNA
Genotypes
Plus strand, as in 23andMe and AncestryDNA files.
- C;TMost notableBadDenys-Drash syndrome
- C;CGoodcommon in clinvar
SNPedia records rs28941778 on the minus strand: (A;G), (G;G). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.
Related
Other WT1 SNPs
- rs28941779A;GFrasier syndrome mutationVery important
- rs28942089A;GDenys-Drash syndromeVery important
- rs121907900A;GWilms tumor susceptibility (predicted)Very important
- rs121907906A;GWilms tumor susceptibility (predicted)Very important
- rs121907908C;TWilms tumor susceptibility (predicted)Very important
- rs121907909A;GWilms tumor susceptibility (predicted)Very important
- rs121907911G;TWilms tumor susceptibility (predicted)Very important
- rs587776573-;ATTTATACCAAATGACAWilms tumor susceptibility (predicted)Very important
Notes
From SNPedia
Notes
rs28941778, also known as Asp396Asn or D396N, is a SNP in the WT1 gene on chromosome 11. This SNP is considered pathogenic (causal) for Denys-Drash syndrome, and may also be associated with nephrotic syndrome, type IV. See also OMIM 607102.0006 This variant meets the criteria published in 2013 by the ACMG regarding incidental findings in exome or genome sequencing, as a variant that they do recommend informing a patient about.
C;T
see discussion at rs28941778
Source and license
Adapted from rs28941778 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.
SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.