rs169547
A SNP in the BRCA2 gene on chromosome 13. Its most notable genotype is C;T: Benign variant
- Gene
- BRCA2
- Location
- Chr 1332,355,250 (GRCh38)
- Highest magnitude
- 1.0Minor
- Tested on
- 23andMe, AncestryDNA, FamilyTreeDNA
- Minor allele frequency
- 2%
Genotypes
Plus strand, as in 23andMe and AncestryDNA files.
SNPedia records rs169547 on the minus strand: (A;A), (A;G), (G;G). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.
Frequency
Share of each genotype in 9 HapMap populations.
- AverageT;T <1% C;T 7% C;C 93%
- European ancestry (Utah)T;T 0% C;T 0% C;C 100%
- Han Chinese (Beijing)T;T 0% C;T 0% C;C 100%
- Japanese (Tokyo)T;T 0% C;T 0% C;C 100%
- Yoruba (Nigeria)T;T 0% C;T 16% C;C 84%
- African ancestry (Southwest US)T;T 0% C;T 20% C;C 80%
- Chinese (Denver)T;T 0% C;T 2% C;C 98%
- Gujarati IndianT;T 0% C;T 6% C;C 94%
- Maasai (Kenya)T;T 1% C;T 12% C;C 87%
- TuscanT;T 0% C;T 6% C;C 94%
Related
Other BRCA2 SNPs
- i5009091D;Ilikely to be BRCA2 variant pathogenic for breast cancerVery important
- rs4987049A;CBRCA2 variant considered pathogenic for breast cancerVery important
- rs11571658-;TTBRCA2 variant considered pathogenic for breast cancerVery important
- rs28897743A;Gconsidered a causal BRCA2 breast cancer mutationVery important
- rs28897746C;TBRCA2 variant considered pathogenic for breast cancerVery important
- rs28897756A;ABRCA2, breast cancer mutationVery important
- rs41293477G;TBRCA2 variant considered pathogenic for breast cancerVery important
- rs41293489C;GBRCA2 variant considered pathogenic for breast cancerVery important
Notes
From SNPedia
Notes
aka c.7397C>T (p.Ala2466Val); a benign BRCA2 variant 23andMe name: i5009334
Source and license
Adapted from rs169547 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.
SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.