rs17367504

A SNP in the MTHFR gene on chromosome 1. Its most notable genotype is G;G: reduction in blood pressure

Gene
MTHFR
Location
Chr 111,802,721 (GRCh38)
Highest magnitude
1.5Minor
Tested on
23andMe, AncestryDNA
Minor allele frequency
11%

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. A;ANot ratedNo summary available.Typical · 0.079% of people
  2. G;GMost notableGoodreduction in blood pressureMinor · 1.51% of people

On SNPedia: (A;A), (G;G). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 11 HapMap populations.

  • AverageA;A 79% G;G 1%
  • European ancestry (Utah)A;A 69% G;G 3%
  • Han Chinese (Beijing)A;A 85% G;G <1%
  • Japanese (Tokyo)A;A 78% G;G <1%
  • Yoruba (Nigeria)A;A 82% G;G 0%
  • African ancestry (Southwest US)A;A 72% G;G 0%
  • Chinese (Denver)A;A 82% G;G 2%
  • Gujarati IndianA;A 71% G;G 3%
  • Luhya (Kenya)A;A 81% G;G <1%
  • Mexican ancestry (Los Angeles)A;A 88% G;G 0%
  • Maasai (Kenya)A;A 82% G;G 0%
  • TuscanA;A 83% G;G 2%

Conditions, medicines and genes

Other MTHFR SNPs

All MTHFR SNPs

Notes

From SNPedia

Notes

Each G allele is associated with 0.89 x odds of high blood pressure, according to 23andMe. 23andMe blog blood pressure High Blood Pressure (Hypertension)

Source and license

Adapted from rs17367504 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.