rs2066462
A SNP in the MTHFR gene on chromosome 1. Its most notable genotype is G;G: common in clinvar
- Gene
- MTHFR
- Location
- Chr 111,794,839 (GRCh38)
- Highest magnitude
- 0.0Typical
- Tested on
- 23andMe
- Minor allele frequency
- 9%
Genotypes
Plus strand, as in 23andMe and AncestryDNA files.
SNPedia records rs2066462 on the minus strand: (C;C). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.
Frequency
Share of each genotype in 4 HapMap populations.
- AverageG;G 78%
- European ancestry (Utah)G;G 77%
- Han Chinese (Beijing)G;G 81%
- Japanese (Tokyo)G;G 72%
- Yoruba (Nigeria)G;G 81%
Related
Other MTHFR SNPs
- rs1801133A;Ahomozygous for C677T of MTHFR = 10-20% efficiency in processing folic acid = high homocysteine, low B12 and folate levelsWorth knowing
- rs1801131G;GNumber of risks. Complex.Worth knowing
- rs17367504G;Greduction in blood pressureMinor
- rs1476413C;Ccommon/normalTypical
- rs1537514G;Gcommon in clinvarTypical
- rs2066470G;Gcommon in clinvarTypical
- rs2274976C;Ccommon in complete genomicsTypical
- rs4846048G;Gcommon in clinvarTypical
Notes
From SNPedia
Notes
A simple and accurate SNP scoring strategy based on typeIIS restriction endonuclease cleavage and matrix-assisted laser desorption/ionization mass spectrometry.
Source and license
Adapted from rs2066462 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.
SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.