rs2274976
A SNP in the MTHFR gene on chromosome 1. Its most notable genotype is C;C: common in complete genomics
- Gene
- MTHFR
- Location
- Chr 111,790,870 (GRCh38)
- Highest magnitude
- 0.0Typical
- Tested on
- 23andMe, AncestryDNA, FamilyTreeDNA
- Minor allele frequency
- 5%
Genotypes
Plus strand, as in 23andMe and AncestryDNA files.
SNPedia records rs2274976 on the minus strand: (G;G). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.
Frequency
Share of each genotype in 10 HapMap populations.
- AverageC;C 88%
- European ancestry (Utah)C;C 89%
- Han Chinese (Beijing)C;C 85%
- Japanese (Tokyo)C;C 80%
- Yoruba (Nigeria)C;C 96%
- African ancestry (Southwest US)C;C 95%
- Chinese (Denver)C;C 81%
- Gujarati IndianC;C 66%
- Mexican ancestry (Los Angeles)C;C 91%
- Maasai (Kenya)C;C 99%
- TuscanC;C 97%
Related
Other MTHFR SNPs
- rs1801133A;Ahomozygous for C677T of MTHFR = 10-20% efficiency in processing folic acid = high homocysteine, low B12 and folate levelsWorth knowing
- rs1801131G;GNumber of risks. Complex.Worth knowing
- rs17367504G;Greduction in blood pressureMinor
- rs1476413C;Ccommon/normalTypical
- rs1537514G;Gcommon in clinvarTypical
- rs2066462G;Gcommon in clinvarTypical
- rs2066470G;Gcommon in clinvarTypical
- rs4846048G;Gcommon in clinvarTypical
Source and license
Adapted from rs2274976 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.
SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.