rs4846048
A SNP in the MTHFR gene on chromosome 1. Its most notable genotype is G;G: common in clinvar
- Gene
- MTHFR
- Location
- Chr 111,786,195 (GRCh38)
- Highest magnitude
- 0.0Typical
- Tested on
- 23andMe, AncestryDNA, FamilyTreeDNA
- Minor allele frequency
- 25%
Genotypes
As shown in 23andMe and AncestryDNA files.
On SNPedia: (G;G). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.
Frequency
Share of each genotype in 11 HapMap populations.
- AverageG;G 11%
- European ancestry (Utah)G;G 6%
- Han Chinese (Beijing)G;G 0%
- Japanese (Tokyo)G;G 0%
- Yoruba (Nigeria)G;G 23%
- African ancestry (Southwest US)G;G 23%
- Chinese (Denver)G;G 2%
- Gujarati IndianG;G 11%
- Luhya (Kenya)G;G 19%
- Mexican ancestry (Los Angeles)G;G 5%
- Maasai (Kenya)G;G 19%
- TuscanG;G 16%
Related
Other MTHFR SNPs
- rs1801133A;Ahomozygous for C677T of MTHFR = 10-20% efficiency in processing folic acid = high homocysteine, low B12 and folate levelsWorth knowing
- rs1801131G;GNumber of risks. Complex.Worth knowing
- rs17367504G;Greduction in blood pressureMinor
- rs1476413C;Ccommon/normalTypical
- rs1537514G;Gcommon in clinvarTypical
- rs2066462G;Gcommon in clinvarTypical
- rs2066470G;Gcommon in clinvarTypical
- rs2274976C;Ccommon in complete genomicsTypical
Notes
From SNPedia
Notes
Associated with lean body mass but not fat body mass in a study of ~1,800 Caucasians
Source and license
Adapted from rs4846048 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.
SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.