rs1799930
A SNP in the NAT2 gene on chromosome 8. Its most notable genotype is A;A: Somewhat increased risk of hearing loss
- Gene
- NAT2
- Location
- Chr 818,400,593 (GRCh38)
- Highest magnitude
- 2.4Worth knowing
- Tested on
- 23andMe, AncestryDNA, FamilyTreeDNA
- Minor allele frequency
- 25%
Genotypes
As shown in 23andMe and AncestryDNA files.
- A;AMost notableBadSomewhat increased risk of hearing loss
- A;GBadPossibly slightly increased risk of hearing loss
- G;GGoodNormal
On SNPedia: (A;A), (A;G), (G;G). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.
Frequency
Share of each genotype in 11 HapMap populations.
- AverageA;A 7% A;G 38% G;G 55%
- European ancestry (Utah)A;A 12% A;G 35% G;G 53%
- Han Chinese (Beijing)A;A 4% A;G 31% G;G 65%
- Japanese (Tokyo)A;A 8% A;G 32% G;G 60%
- Yoruba (Nigeria)A;A 5% A;G 39% G;G 56%
- African ancestry (Southwest US)A;A 2% A;G 47% G;G 51%
- Chinese (Denver)A;A 6% A;G 41% G;G 53%
- Gujarati IndianA;A 13% A;G 48% G;G 40%
- Luhya (Kenya)A;A 8% A;G 39% G;G 53%
- Mexican ancestry (Los Angeles)A;A 2% A;G 29% G;G 70%
- Maasai (Kenya)A;A 9% A;G 43% G;G 48%
- TuscanA;A 10% A;G 39% G;G 51%
Related
Conditions, medicines and genes
Other NAT2 SNPs
- rs1208A;ANo summary available.Typical
- rs1041983C;Ccommon in clinvarTypical
- rs1799929C;CNo summary available.Typical
- rs1799931G;Gcommon in clinvarTypical
- rs1801279G;Gcommon in complete genomicsTypical
- rs1801280T;Tcommon in clinvarTypical
- rs4986996G;Gcommon in complete genomicsTypical
- rs4986997A;Acommon in complete genomicsTypical
Genosets
- Gs140NAT2 slow metabolizerWorth knowing
- Gs139NAT2 intermediate metabolizerMinor
- Gs138NAT2 rapid metabolizerMinor
Genosets combine several genotypes. Twofold checks them in your report.
Notes
From SNPedia
Show notes, about 180 words
rs1799930 is a SNP in the NAT2 gene, potentially encoding a variant detoxifying protein known as an N-acetyltransferase, but which NAT2 variant depends on which other NAT2 SNPs were also inherited. See the discussion of the NAT2 gene for a more complete explanation. Also known as G590A. The risk allele for this SNP is rs1799930(A). A user has posted a question on the Discussion page for this SNP. In an age-related hearing impairment study of 2500+ Caucasians ranging in age from 53 to 67, those with the AA genotype for NAT2*6A had worse hearing compared with heterozygous or homozygous GG subjects (p=0.013). No association between NAT2*6A and AHRI was found in a study of 265 elderly UK volunteers.
A;A
Two studies have shown somewhat increased risk for age-related hearing impairment for rs1799930(A;A) individuals; one study has found no such association. See main rs-page for details.
A;G
One 2007 study reports 5.2x higher risk for Age Related Hearing Impairment(ARHI) for rs1799930(A;G) carriers, but no study since then has replicated this to our knowledge.
G;G
common for Caucasians on the 23andme platform
References
Source and license
Adapted from rs1799930 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.
SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.