rs1801280
A SNP in the NAT2 gene on chromosome 8. Its most notable genotype is T;T: common in clinvar
- Gene
- NAT2
- Location
- Chr 818,400,344 (GRCh38)
- Highest magnitude
- 0.0Typical
- Tested on
- 23andMe, AncestryDNA, FamilyTreeDNA
- Minor allele frequency
- 30%
Genotypes
As shown in 23andMe and AncestryDNA files.
On SNPedia: (T;T). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.
Frequency
Share of each genotype in 4 HapMap populations.
- AverageT;T 69%
- European ancestry (Utah)T;T 31%
- Han Chinese (Beijing)T;T 96%
- Japanese (Tokyo)T;T 93%
- Yoruba (Nigeria)T;T 56%
Related
Other NAT2 SNPs
- rs1799930A;ASomewhat increased risk of hearing lossWorth knowing
- rs1208A;ANo summary available.Typical
- rs1041983C;Ccommon in clinvarTypical
- rs1799929C;CNo summary available.Typical
- rs1799931G;Gcommon in clinvarTypical
- rs1801279G;Gcommon in complete genomicsTypical
- rs4986996G;Gcommon in complete genomicsTypical
- rs4986997A;Acommon in complete genomicsTypical
Genosets
- Gs140NAT2 slow metabolizerWorth knowing
- Gs154NAT2 Slow metabolizerWorth knowing
- Gs156NAT2 Rapid metabolizer.Worth knowing
- Gs139NAT2 intermediate metabolizerMinor
- Gs138NAT2 rapid metabolizerMinor
Genosets combine several genotypes. Twofold checks them in your report.
Notes
From SNPedia
Notes
rs1801280, also known as T341C, is a SNP in the NAT2 gene, potentially encoding a variant detoxifying protein known as an N-acetyltransferase, but which NAT2 variant depends on which other NAT2 SNPs were also inherited. See the discussion of the NAT2 gene for a more complete explanation. The allele associated with slow NAT2 metabolization for this SNP is rs1801280(C). Genosets gs154 and gs156 evaluate predicated NAT2 metabolizer phenotype based on rs1041983 and rs1801280.
Source and license
Adapted from rs1801280 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.
SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.