rs1800693

A SNP in the TNFRSF1A gene on chromosome 12. Its most notable genotype is C;C: slight (1.4x) increase in risk for multiple sclerosis

Gene
TNFRSF1A
Location
Chr 126,330,843 (GRCh38)
Highest magnitude
1.4Minor
Tested on
23andMe, AncestryDNA
Minor allele frequency
32%

Genotypes

Plus strand, as in 23andMe and AncestryDNA files.

  1. T;TGoodcommon/normalTypical · 0.050% of people
  2. C;TBadslight (1.2x) increase in risk for multiple sclerosisMinor · 1.239% of people
  3. C;CMost notableBadslight (1.4x) increase in risk for multiple sclerosisMinor · 1.411% of people

SNPedia records rs1800693 on the minus strand: (A;A), (A;G), (G;G). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 11 HapMap populations.

  • AverageT;T 50% C;T 39% C;C 11%
  • European ancestry (Utah)T;T 28% C;T 47% C;C 25%
  • Han Chinese (Beijing)T;T 80% C;T 20% C;C <1%
  • Japanese (Tokyo)T;T 66% C;T 32% C;C 3%
  • Yoruba (Nigeria)T;T 46% C;T 42% C;C 12%
  • African ancestry (Southwest US)T;T 42% C;T 46% C;C 12%
  • Chinese (Denver)T;T 79% C;T 19% C;C 2%
  • Gujarati IndianT;T 46% C;T 41% C;C 14%
  • Luhya (Kenya)T;T 37% C;T 48% C;C 15%
  • Mexican ancestry (Los Angeles)T;T 50% C;T 40% C;C 10%
  • Maasai (Kenya)T;T 42% C;T 46% C;C 12%
  • TuscanT;T 36% C;T 44% C;C 20%

Conditions, medicines and genes

Other TNFRSF1A SNPs

All TNFRSF1A SNPs

Notes

From SNPedia

Notes

rs1800693 is a SNP in the tumor necrosis factor receptor superfamily, member 1A TNFRSF1A gene. A large study (~5,000 patients) found two SNPs in the TNFRSF1A gene that each (independently) increase risk for multiple sclerosis, rs1800693 and rs4149584. This SNP, rs1800693, is more common but increases risk less; the odds ratio is reported as 1.2 (CI: 1.10-1.31, p=1.6x10(-11)).

Source and license

Adapted from rs1800693 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.