rs4149584

A SNP in the TNFRSF1A gene on chromosome 12. Its most notable genotype is C;C: common in clinvar

Gene
TNFRSF1A
Location
Chr 126,333,477 (GRCh38)
Highest magnitude
0.0Typical
Tested on
23andMe, AncestryDNA
Minor allele frequency
1%

Genotypes

Plus strand, as in 23andMe and AncestryDNA files.

  1. C;CMost notableGoodcommon in clinvarTypical · 0.098% of people

SNPedia records rs4149584 on the minus strand: (G;G). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 4 HapMap populations.

  • AverageC;C 98%
  • European ancestry (Utah)C;C 94%
  • Han Chinese (Beijing)C;C 100%
  • Japanese (Tokyo)C;C 100%
  • Yoruba (Nigeria)C;C 100%

Conditions, medicines and genes

Other TNFRSF1A SNPs

All TNFRSF1A SNPs

Notes

From SNPedia

Notes

rs4149584 is a SNP in the tumor necrosis factor receptor superfamily, member 1A TNFRSF1A gene. A large study (~5,000 patients) found two SNPs in the TNFRSF1A gene that each (independently) increase risk for multiple sclerosis, rs1800693 and rs4149584. This SNP, rs4149584, was less common but was associated with more risk; the odds ratio is reported as 1.6.

Source and license

Adapted from rs4149584 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.