rs4149579

A SNP in the TNFRSF1A gene on chromosome 12. Its most notable genotype is T;T: Tumor Necrosis Factor 1A Receptor Intron Variant Homozygous

Gene
TNFRSF1A
Location
Chr 126,338,191 (GRCh38)
Highest magnitude
1.0Minor
Tested on
23andMe, AncestryDNA, FamilyTreeDNA
Minor allele frequency
4%

Genotypes

Plus strand, as in 23andMe and AncestryDNA files.

  1. T;TMost notableNot ratedTumor Necrosis Factor 1A Receptor Intron Variant HomozygousMinor · 1.0<1% of people
  2. C;CGoodcommon in complete genomicsTypical · 0.092% of people

SNPedia records rs4149579 on the minus strand: (A;A), (G;G). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 7 HapMap populations.

  • AverageT;T <1% C;C 92%
  • European ancestry (Utah)T;T <1% C;C 84%
  • Han Chinese (Beijing)T;T 0% C;C 99%
  • African ancestry (Southwest US)T;T 0% C;C 98%
  • Chinese (Denver)T;T 0% C;C 99%
  • Gujarati IndianT;T 0% C;C 84%
  • Mexican ancestry (Los Angeles)T;T 0% C;C 95%
  • TuscanT;T 0% C;C 84%

Other TNFRSF1A SNPs

All TNFRSF1A SNPs

Notes

From SNPedia

Notes

c.39+3585G>A is a rare SNV in an intronic region of TNFRSF1A, the gene for tumor necrosis factor receptor 1A.

T;T

Homozygous for variant SNP in intron of TNF alpha receptor, unknown significance

Source and license

Adapted from rs4149579 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.