rs1800937
A SNP in the MSH6 gene on chromosome 2. Its most notable genotype is A;C: Lynch syndrome, pathogenic mutation
- Gene
- MSH6
- Location
- Chr 247,798,625 (GRCh38)
- Highest magnitude
- 6.0Very important
- Tested on
- 23andMe
- Minor allele frequency
- 5%
Genotypes
As shown in 23andMe and AncestryDNA files.
- A;CMost notableBadLynch syndrome, pathogenic mutation
- C;CGoodcommon in clinvar
- C;GBadLynch syndrome, pathogenic mutation
- C;TGoodbenign polymorphism
- T;TGoodbenign polymorphism
On SNPedia: (A;C), (C;C), (C;G), (C;T), (T;T). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.
Frequency
Share of each genotype in 4 HapMap populations.
- AverageA;C 0% C;C 94% C;G 0% C;T 5% T;T <1%
- European ancestry (Utah)A;C 0% C;C 75% C;G 0% C;T 22% T;T 3%
- Han Chinese (Beijing)A;C 0% C;C 100% C;G 0% C;T 0% T;T 0%
- Japanese (Tokyo)A;C 0% C;C 100% C;G 0% C;T 0% T;T 0%
- Yoruba (Nigeria)A;C 0% C;C 100% C;G 0% C;T 0% T;T 0%
Related
Other MSH6 SNPs
- rs587776706T;TMismatch repair cancer syndrome (predicted)Very important
- rs63749821-;TALikely miscall in Ancestry data; otherwise, Lynch syndrome, pathogenic mutationVery important
- rs63749843C;TLynch syndrome, pathogenic mutationVery important
- rs63749873C;GLynch syndrome, pathogenic mutationVery important
- rs63749874-;AAGALynch syndrome, pathogenic mutationVery important
- rs63749919A;GLynch syndromeVery important
- rs63749938-;ALynch Syndrome, pathogenic mutationVery important
- rs63749942-;CGTLynch syndrome, pathogenic mutationVery important
Source and license
Adapted from rs1800937 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.
SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.