rs63749873
A SNP in the MSH6 gene on chromosome 2. Its most notable genotype is C;G: Lynch syndrome, pathogenic mutation
- Gene
- MSH6
- Location
- Chr 247,795,903 (GRCh38)
- Highest magnitude
- 6.0Very important
- Tested on
- 23andMe, AncestryDNA
Genotypes
As shown in 23andMe and AncestryDNA files.
- C;CGoodcommon in clinvar
- C;GMost notableBadLynch syndrome, pathogenic mutation
On SNPedia: (C;C), (C;G). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.
Related
Conditions, medicines and genes
Other MSH6 SNPs
- rs587776706T;TMismatch repair cancer syndrome (predicted)Very important
- rs1800937A;CLynch syndrome, pathogenic mutationVery important
- rs63749821-;TALikely miscall in Ancestry data; otherwise, Lynch syndrome, pathogenic mutationVery important
- rs63749843C;TLynch syndrome, pathogenic mutationVery important
- rs63749874-;AAGALynch syndrome, pathogenic mutationVery important
- rs63749919A;GLynch syndromeVery important
- rs63749938-;ALynch Syndrome, pathogenic mutationVery important
- rs63749942-;CGTLynch syndrome, pathogenic mutationVery important
Notes
From SNPedia
Notes
rs63749873, also known as c.467C>G, p.Ser156Ter and S156*, represents a very rare variant in the MSH6 gene on chromosome 2. Several sources, including ClinVar and Insight, all classify the rs63749873(G) allele as a pathogenic mutation associated with Lynch syndrome.
C;G
see discussion at rs63749873.
Source and license
Adapted from rs63749873 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.
SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.