rs587776706
A SNP in the MSH6 gene on chromosome 2. Its most notable genotype is T;T: Mismatch repair cancer syndrome (predicted)
- Gene
- MSH6
- Location
- Chr 247,805,694 (GRCh38)
- Highest magnitude
- 7.0Very important
- Tested on
- AncestryDNA
Genotypes
As shown in 23andMe and AncestryDNA files.
- -;-Goodcommon in clinvar
- -;TBadCarrier of mismatch cancer repair syndrome mutation; effect unknown
- T;TMost notableBadMismatch repair cancer syndrome (predicted)
On SNPedia: (-;-), (-;T), (T;T). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.
Related
Other MSH6 SNPs
- rs1800937A;CLynch syndrome, pathogenic mutationVery important
- rs63749821-;TALikely miscall in Ancestry data; otherwise, Lynch syndrome, pathogenic mutationVery important
- rs63749843C;TLynch syndrome, pathogenic mutationVery important
- rs63749873C;GLynch syndrome, pathogenic mutationVery important
- rs63749874-;AAGALynch syndrome, pathogenic mutationVery important
- rs63749919A;GLynch syndromeVery important
- rs63749938-;ALynch Syndrome, pathogenic mutationVery important
- rs63749942-;CGTLynch syndrome, pathogenic mutationVery important
Notes
From SNPedia
Notes
c.3633dupT (p.Val1212Cysfs) 23andMe name: i5037828
-;T
Cited only once (in 2005), the effect on heterozygous carriers of this rare allele appear to be unknown; it may have Lynch syndrome characteristics, but may not. Anyone with further information about this mutation and it's consequences is encouraged to contact us.
T;T
A 2005 publication (see citations) reports this genotype as being associated with MRCS.
Source and license
Adapted from rs587776706 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.
SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.