rs1801272
A SNP in the CYP2A6 gene on chromosome 19. Its most notable genotype is T;T: Reduced CYP2A6 metabolism; impaired nicotine metabolism?
- Gene
- CYP2A6
- Location
- Chr 1940,848,628 (GRCh38)
- Highest magnitude
- 2.0Worth knowing
- Tested on
- 23andMe, AncestryDNA
- Minor allele frequency
- 1%
Genotypes
Plus strand, as in 23andMe and AncestryDNA files.
- T;TMost notableNot ratedReduced CYP2A6 metabolism; impaired nicotine metabolism?
- A;TNot ratedReduced CYP2A6 metabolism; impaired nicotine metabolism?
- A;AGoodcommon in clinvar
SNPedia records rs1801272 on the minus strand: (A;A), (A;T), (T;T). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.
Frequency
Share of each genotype in 4 HapMap populations.
- AverageT;T 0% A;T 3% A;A 97%
- European ancestry (Utah)T;T 0% A;T 9% A;A 91%
- Han Chinese (Beijing)T;T 0% A;T 0% A;A 100%
- Japanese (Tokyo)T;T 0% A;T 5% A;A 96%
- Yoruba (Nigeria)T;T 0% A;T 0% A;A 100%
Related
Other CYP2A6 SNPs
- rs5031017A;ATwo copies of CYP2A6*5 non-functioning variant; impaired nicotine metabolismWorth knowing
- rs28399433C;CReduced CYP2A6 metabolism; impaired nicotine metabolism?Worth knowing
- rs28399444-;-Reduced CYP2A6 metabolism; impaired nicotine metabolism?Worth knowing
- rs4997557G;Gcommon in complete genomicsTypical
- rs28399454C;Ccommon in complete genomicsTypical
Notes
From SNPedia
Notes
minor form is a slow metaboliser according to pharmgkb
Source and license
Adapted from rs1801272 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.
SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.