rs28399454
A SNP in the CYP2A6 gene on chromosome 19. Its most notable genotype is C;C: common in complete genomics
- Gene
- CYP2A6
- Location
- Chr 1940,845,362 (GRCh38)
- Highest magnitude
- 0.0Typical
- Tested on
- 23andMe, AncestryDNA, FamilyTreeDNA
- Minor allele frequency
- 2%
Genotypes
Plus strand, as in 23andMe and AncestryDNA files.
SNPedia records rs28399454 on the minus strand: (G;G). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.
Frequency
Share of each genotype in 4 HapMap populations.
- AverageC;C 86%
- European ancestry (Utah)C;C 99%
- Yoruba (Nigeria)C;C 77%
- African ancestry (Southwest US)C;C 81%
- Luhya (Kenya)C;C 89%
Related
Other CYP2A6 SNPs
- rs1801272T;TReduced CYP2A6 metabolism; impaired nicotine metabolism?Worth knowing
- rs5031017A;ATwo copies of CYP2A6*5 non-functioning variant; impaired nicotine metabolismWorth knowing
- rs28399433C;CReduced CYP2A6 metabolism; impaired nicotine metabolism?Worth knowing
- rs28399444-;-Reduced CYP2A6 metabolism; impaired nicotine metabolism?Worth knowing
- rs4997557G;Gcommon in complete genomicsTypical
Notes
From SNPedia
Notes
CYP2B6 (c.516G-->T) and CYP2A6 (*9B and/or *17) polymorphisms are independent predictors of efavirenz plasma concentrations in HIV-infected patients.
Source and license
Adapted from rs28399454 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.
SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.