rs5031017

A SNP in the CYP2A6 gene on chromosome 19. Its most notable genotype is A;A: Two copies of CYP2A6*5 non-functioning variant; impaired nicotine metabolism

Gene
CYP2A6
Location
Chr 1940,843,845 (GRCh38)
Highest magnitude
2.0Worth knowing
Tested on
23andMe, AncestryDNA

Genotypes

Plus strand, as in 23andMe and AncestryDNA files.

  1. C;CNot ratednormalTypical · 0.076% of people
  2. A;CNot ratedOne copy of CYP2A6*5 non-functioning variant; impaired nicotine metabolismMinor · 1.524% of people
  3. A;AMost notableNot ratedTwo copies of CYP2A6*5 non-functioning variant; impaired nicotine metabolismWorth knowing · 2.00% of people

SNPedia records rs5031017 on the minus strand: (G;G), (G;T), (T;T). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in one HapMap population.

  • Yoruba (Nigeria)C;C 76% A;C 24% A;A 0%

Conditions, medicines and genes

Other CYP2A6 SNPs

All CYP2A6 SNPs

Notes

From SNPedia

Notes

rs5031017 in the CYP2A6 gene, also known as G479V, 1436G>T or 6582G>T, the T allele indicates the CYP2A6*5 inactive form of the gene. reports that poor metabolizers (such as those with inactive forms of CYP2A6), among male smokers and compared to normal smokers, smoked fewer cigarettes, took longer to smoke regularly, and if they had stopped smoking, waited a shorter period of time before making the decision. Unfortunately, this group also had a lower likelihood of smoking cessation. Smoking

Source and license

Adapted from rs5031017 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.