rs28399444
A SNP in the CYP2A6 gene on chromosome 19. Its most notable genotype is -;-: Reduced CYP2A6 metabolism; impaired nicotine metabolism?
- Gene
- CYP2A6
- Location
- Chr 1941,354,190 (GRCh38)
- Highest magnitude
- 2.0Worth knowing
- Tested on
- 23andMe, AncestryDNA
Genotypes
As shown in 23andMe and AncestryDNA files.
- -;-Most notableBadReduced CYP2A6 metabolism; impaired nicotine metabolism?
- -;AANot ratedReduced CYP2A6 metabolism; impaired nicotine metabolism?
- AA;AAGoodNo summary available.
- AAG;AAGGoodcommon on affy axiom data
On SNPedia: (-;-), (-;AA), (AA;AA), (AAG;AAG). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.
Related
Other CYP2A6 SNPs
- rs1801272T;TReduced CYP2A6 metabolism; impaired nicotine metabolism?Worth knowing
- rs5031017A;ATwo copies of CYP2A6*5 non-functioning variant; impaired nicotine metabolismWorth knowing
- rs28399433C;CReduced CYP2A6 metabolism; impaired nicotine metabolism?Worth knowing
- rs4997557G;Gcommon in complete genomicsTypical
- rs28399454C;Ccommon in complete genomicsTypical
Notes
From SNPedia
Notes
rs28399444 is a truncated non-functioning variant of CYP2A6 known as CYP2A6*20
Source and license
Adapted from rs28399444 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.
SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.