rs1801406
A SNP in the BRCA2 gene on chromosome 13. Its most notable genotype is A;A: common in clinvar
- Gene
- BRCA2
- Location
- Chr 1332,337,751 (GRCh38)
- Highest magnitude
- 0.0Typical
- Tested on
- 23andMe, AncestryDNA, FamilyTreeDNA
- Minor allele frequency
- 28%
Genotypes
As shown in 23andMe and AncestryDNA files.
On SNPedia: (A;A), (A;G), (G;G). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.
Frequency
Share of each genotype in 11 HapMap populations.
- AverageA;A 55% A;G 38% G;G 6%
- European ancestry (Utah)A;A 55% A;G 40% G;G 5%
- Han Chinese (Beijing)A;A 40% A;G 54% G;G 6%
- Japanese (Tokyo)A;A 24% A;G 57% G;G 20%
- Yoruba (Nigeria)A;A 63% A;G 33% G;G 4%
- African ancestry (Southwest US)A;A 65% A;G 32% G;G 4%
- Chinese (Denver)A;A 46% A;G 41% G;G 13%
- Gujarati IndianA;A 50% A;G 47% G;G 4%
- Luhya (Kenya)A;A 74% A;G 25% G;G 2%
- Mexican ancestry (Los Angeles)A;A 59% A;G 38% G;G 3%
- Maasai (Kenya)A;A 80% A;G 19% G;G 1%
- TuscanA;A 56% A;G 34% G;G 10%
Related
Conditions, medicines and genes
Other BRCA2 SNPs
- i5009091D;Ilikely to be BRCA2 variant pathogenic for breast cancerVery important
- rs4987049A;CBRCA2 variant considered pathogenic for breast cancerVery important
- rs11571658-;TTBRCA2 variant considered pathogenic for breast cancerVery important
- rs28897743A;Gconsidered a causal BRCA2 breast cancer mutationVery important
- rs28897746C;TBRCA2 variant considered pathogenic for breast cancerVery important
- rs28897756A;ABRCA2, breast cancer mutationVery important
- rs41293477G;TBRCA2 variant considered pathogenic for breast cancerVery important
- rs41293489C;GBRCA2 variant considered pathogenic for breast cancerVery important
Notes
From SNPedia
Notes
rs1801406, also known as c.3396A>C, p.Lys1132Asn and K1132N, is a variant in the BRCA2 gene classified as benign in ClinVar.
Source and license
Adapted from rs1801406 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.
SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.