rs1801426
A SNP in the BRCA2 gene on chromosome 13. Its most notable genotype is G;G.
- Gene
- BRCA2
- Location
- Chr 1332,398,747 (GRCh38)
- Highest magnitude
- 2.0Worth knowing
- Tested on
- 23andMe, AncestryDNA, FamilyTreeDNA
- Minor allele frequency
- 4%
Genotypes
As shown in 23andMe and AncestryDNA files.
- A;AGoodcommon in complete genomics
- A;GNot ratedBenign or at worst a very minor risk factor
- G;GMost notableNot ratedNo summary available.
On SNPedia: (A;A), (A;G), (G;G). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.
Frequency
Share of each genotype in 10 HapMap populations.
- AverageA;A 89% A;G 11% G;G <1%
- European ancestry (Utah)A;A 100% A;G 0% G;G 0%
- Han Chinese (Beijing)A;A 92% A;G 8% G;G 0%
- Japanese (Tokyo)A;A 97% A;G 4% G;G 0%
- Yoruba (Nigeria)A;A 69% A;G 29% G;G 1%
- African ancestry (Southwest US)A;A 81% A;G 19% G;G 0%
- Chinese (Denver)A;A 92% A;G 8% G;G 0%
- Luhya (Kenya)A;A 81% A;G 19% G;G 0%
- Mexican ancestry (Los Angeles)A;A 86% A;G 14% G;G 0%
- Maasai (Kenya)A;A 96% A;G 4% G;G <1%
- TuscanA;A 99% A;G 1% G;G 0%
Related
Conditions, medicines and genes
Other BRCA2 SNPs
- i5009091D;Ilikely to be BRCA2 variant pathogenic for breast cancerVery important
- rs4987049A;CBRCA2 variant considered pathogenic for breast cancerVery important
- rs11571658-;TTBRCA2 variant considered pathogenic for breast cancerVery important
- rs28897743A;Gconsidered a causal BRCA2 breast cancer mutationVery important
- rs28897746C;TBRCA2 variant considered pathogenic for breast cancerVery important
- rs28897756A;ABRCA2, breast cancer mutationVery important
- rs41293477G;TBRCA2 variant considered pathogenic for breast cancerVery important
- rs41293489C;GBRCA2 variant considered pathogenic for breast cancerVery important
Notes
From SNPedia
Notes
This SNP, a variant in the BRCA2 gene, is 1 of 25 SNPs reported to represent independently minor, but cumulatively significant, increased risk for breast cancer. For details of all 25 SNPs in this group, along with the two methods used to calculate overall risk estimates for breast cancer, refer to the SNPedia breast cancer entry. For this particular SNP, the risk (minor) allele is (G). 23andMe name: i5009256
A;G
see discussion via main rs=page
Source and license
Adapted from rs1801426 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.
SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.