rs1805005
A SNP in the MC1R gene on chromosome 16. Its most notable genotype is G;G: common in clinvar
- Gene
- MC1R
- Location
- Chr 1689,919,436 (GRCh38)
- Highest magnitude
- 0.0Typical
- Tested on
- 23andMe, AncestryDNA, FamilyTreeDNA
- Minor allele frequency
- 5%
Genotypes
As shown in 23andMe and AncestryDNA files.
On SNPedia: (G;G), (G;T). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.
Frequency
Share of each genotype in 10 HapMap populations.
- AverageG;G 94% G;T 6%
- European ancestry (Utah)G;G 84% G;T 16%
- Han Chinese (Beijing)G;G 99% G;T 2%
- Japanese (Tokyo)G;G 99% G;T <1%
- Yoruba (Nigeria)G;G 99% G;T <1%
- Chinese (Denver)G;G 99% G;T <1%
- Gujarati IndianG;G 99% G;T 1%
- Luhya (Kenya)G;G 96% G;T 4%
- Mexican ancestry (Los Angeles)G;G 91% G;T 9%
- Maasai (Kenya)G;G 99% G;T <1%
- TuscanG;G 72% G;T 25%
Related
Other MC1R SNPs
- rs11547464A;Ared hairImportant
- rs1805007T;Tincreased response to anesthetics; 13-20x higher likelihood of red hair; increased risk of melanomaImportant
- rs1805006A;AMelanoma risk; red hairImportant
- rs1805008T;T~7-10x higher likelihood of red hair; higher risk of melanomaImportant
- rs1805009C;Cred hair possible, higher risk of melanomaImportant
- rs885479A;Alighter skin colorWorth knowing
- rs2228479G;Gcommon in clinvarTypical
Notes
From SNPedia
Notes
rs1805005, known as Val60Leu or V60L, is a SNP in the MC1R gene associated with light blond hair color in one study. The risk allele is rs1805005(T), compared with the wild-type rs1805005(G) allele. See also OMIM 155555.0006
Source and license
Adapted from rs1805005 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.
SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.