rs1805006
A SNP in the MC1R gene on chromosome 16. Its most notable genotype is A;A: Melanoma risk; red hair
- Gene
- MC1R
- Location
- Chr 1689,919,510 (GRCh38)
- Highest magnitude
- 3.0Important
- Tested on
- 23andMe, AncestryDNA, FamilyTreeDNA
- Minor allele frequency
- <1%
Genotypes
As shown in 23andMe and AncestryDNA files.
- A;AMost notableBadMelanoma risk; red hair
- A;CBadRed hair carrier, higher risk of melanoma
- C;CGoodcommon in complete genomics
On SNPedia: (A;A), (A;C), (C;C). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.
Related
Other MC1R SNPs
- rs11547464A;Ared hairImportant
- rs1805007T;Tincreased response to anesthetics; 13-20x higher likelihood of red hair; increased risk of melanomaImportant
- rs1805008T;T~7-10x higher likelihood of red hair; higher risk of melanomaImportant
- rs1805009C;Cred hair possible, higher risk of melanomaImportant
- rs885479A;Alighter skin colorWorth knowing
- rs1805005G;Gcommon in clinvarTypical
- rs2228479G;Gcommon in clinvarTypical
Notes
From SNPedia
Notes
rs1805006, known as Asp84Glu or D84E, is one of several SNPs in the MC1R gene associated with higher risk of melanoma. The risk allele is rs1805006(A), compared with the wild-type rs1805006(C) allele. Allelic odds ratio for pale skin(P-value)=5.19(<1.0e-5)MC1R*D84E rs1805006 http://genepi.qimr.edu.au/contents/p/staff/Duffyetal_JID_520-528Jan10.pdf See also OMIM 155555.0003
A;C
this genotype raises the melanoma risk 42% (95% CI, 15–76%) higher than that among persons not carrying a similar allele.
References
Source and license
Adapted from rs1805006 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.
SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.