rs1805009
A SNP in the MC1R gene on chromosome 16. Its most notable genotype is C;C: red hair possible, higher risk of melanoma
- Gene
- MC1R
- Location
- Chr 1689,920,138 (GRCh38)
- Highest magnitude
- 3.0Important
- Tested on
- AncestryDNA
- Minor allele frequency
- <1%
Genotypes
As shown in 23andMe and AncestryDNA files.
- C;CMost notableBadred hair possible, higher risk of melanoma
- C;GBadRed hair carrier, higher risk of melanoma
- G;GGoodcommon in clinvar
On SNPedia: (C;C), (C;G), (G;G). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.
Related
Other MC1R SNPs
- rs11547464A;Ared hairImportant
- rs1805007T;Tincreased response to anesthetics; 13-20x higher likelihood of red hair; increased risk of melanomaImportant
- rs1805006A;AMelanoma risk; red hairImportant
- rs1805008T;T~7-10x higher likelihood of red hair; higher risk of melanomaImportant
- rs885479A;Alighter skin colorWorth knowing
- rs1805005G;Gcommon in clinvarTypical
- rs2228479G;Gcommon in clinvarTypical
Genosets
Genosets combine several genotypes. Twofold checks them in your report.
Notes
From SNPedia
Notes
rs1805009, known as Asp294His or D294H and located in the MC1R gene, is a variant associated with red hair (redheads) and low tanning in one study. , Reported as i3002507 by 23andMe in January 2015. The risk allele is rs1805009(C), compared with the wild-type rs1805009(G) allele. See also OMIM 155555.0001 blog about designing melanocortin analogs specific to these genotypes.
C;G
this genotype raises the melanoma risk 42% (95% CI, 15–76%) higher than that among persons not carrying a similar allele.
References
Source and license
Adapted from rs1805009 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.
SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.