rs2228479
A SNP in the MC1R gene on chromosome 16. Its most notable genotype is G;G: common in clinvar
- Gene
- MC1R
- Location
- Chr 1689,919,532 (GRCh38)
- Highest magnitude
- 0.0Typical
- Tested on
- 23andMe, AncestryDNA, FamilyTreeDNA
- Minor allele frequency
- 9%
Genotypes
As shown in 23andMe and AncestryDNA files.
On SNPedia: (G;G). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.
Frequency
Share of each genotype in 9 HapMap populations.
- AverageG;G 82%
- European ancestry (Utah)G;G 88%
- Han Chinese (Beijing)G;G 57%
- Japanese (Tokyo)G;G 80%
- African ancestry (Southwest US)G;G 97%
- Chinese (Denver)G;G 50%
- Gujarati IndianG;G 94%
- Luhya (Kenya)G;G 99%
- Mexican ancestry (Los Angeles)G;G 90%
- TuscanG;G 88%
Related
Other MC1R SNPs
- rs11547464A;Ared hairImportant
- rs1805007T;Tincreased response to anesthetics; 13-20x higher likelihood of red hair; increased risk of melanomaImportant
- rs1805006A;AMelanoma risk; red hairImportant
- rs1805008T;T~7-10x higher likelihood of red hair; higher risk of melanomaImportant
- rs1805009C;Cred hair possible, higher risk of melanomaImportant
- rs885479A;Alighter skin colorWorth knowing
- rs1805005G;Gcommon in clinvarTypical
Notes
From SNPedia
Notes
rs2228479, known as Val92Met or V92M, is one of several SNPs in the MC1R gene commonly associated with red (or blond) hair and poor tanning, but note its high presence in one Asian population PMID 7581459, PMID 16463023 The risk allele is rs2228479(A), compared with the wild-type rs2228479(G) allele. See also OMIM 155555.0002
G;G
common for Caucasians on the 23andme platform
Source and license
Adapted from rs2228479 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.
SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.