rs1805123
A SNP in the KCNH2 gene on chromosome 7. Its most notable genotype is T;T: common in clinvar
- Gene
- KCNH2
- Location
- Chr 7150,948,446 (GRCh38)
- Highest magnitude
- 0.0Typical
- Tested on
- 23andMe, AncestryDNA, FamilyTreeDNA
- Minor allele frequency
- 13%
Genotypes
Plus strand, as in 23andMe and AncestryDNA files.
SNPedia records rs1805123 on the minus strand: (A;A). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.
Frequency
Share of each genotype in 11 HapMap populations.
- AverageT;T 81%
- European ancestry (Utah)T;T 58%
- Han Chinese (Beijing)T;T 93%
- Japanese (Tokyo)T;T 93%
- Yoruba (Nigeria)T;T 97%
- African ancestry (Southwest US)T;T 86%
- Chinese (Denver)T;T 89%
- Gujarati IndianT;T 61%
- Luhya (Kenya)T;T 98%
- Mexican ancestry (Los Angeles)T;T 72%
- Maasai (Kenya)T;T 93%
- TuscanT;T 52%
Related
Other KCNH2 SNPs
- rs189014161C;GLong QT syndrome; other possible cardiac issuesVery important
- rs9333649C;TRomano-Ward Long QT SyndromeVery important
- rs12720441A;GRomano-Ward Long QT SyndromeVery important
- rs28928904A;TRomano-Ward Long QT SyndromeVery important
- rs121912505C;TRomano-Ward Long QT SyndromeVery important
- rs121912506C;TRomano-Ward Long QT SyndromeVery important
- rs121912507C;TRomano-Ward Long QT SyndromeVery important
- rs121912508A;GRomano-Ward Long QT SyndromeVery important
Source and license
Adapted from rs1805123 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.
SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.