rs2179922
A SNP in the ESR1 gene on chromosome 6. Its most notable genotype is A;A: males 1-2cm shorter on average
- Gene
- ESR1
- Location
- Chr 6151,975,965 (GRCh38)
- Highest magnitude
- 0.0Typical
- Tested on
- 23andMe
- Minor allele frequency
- 15%
Genotypes
As shown in 23andMe and AncestryDNA files.
- A;AMost notableNot ratedmales 1-2cm shorter on average
- A;GNot ratedNo summary available.
- G;GNot ratedcommon
On SNPedia: (A;A), (A;G), (G;G). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.
Frequency
Share of each genotype in 4 HapMap populations.
- AverageA;A 6% A;G 24% G;G 70%
- European ancestry (Utah)A;A 0% A;G 6% G;G 94%
- Han Chinese (Beijing)A;A 9% A;G 42% G;G 49%
- Japanese (Tokyo)A;A 14% A;G 43% G;G 43%
- Yoruba (Nigeria)A;A 0% A;G 5% G;G 95%
Related
Conditions, medicines and genes
Other ESR1 SNPs
- rs9340799G;GWomen have 10x risk of Endometriosis, but half the risk of Endometrial Cancer and 0.76x less cognitive impairment.Important
- rs104893956C;TCarrier for an estrogen resistance mutationImportant
- rs121913044A;TCarrier for an estrogen resistance mutationImportant
- rs397509428G;TCarrier for an estrogen resistance mutationImportant
- rs2881766G;TSlightly increased risk for pregnancy-induced hypertensionMinor
- rs2295190T;TSlightly increased risk for ovarian cancer in womenMinor
- rs728524A;Acommon in complete genomicsTypical
- rs2228480G;Gcommon in complete genomicsTypical
Notes
From SNPedia
Notes
A study of 1153 elderly Swedish men (age 70) concluded that rs2179922(G;G) homozygotes were between 0.90 - 2.3cm taller on average than either (A;G) or (A;A) genotypes. [No such association with height was seen for females.]
Source and license
Adapted from rs2179922 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.
SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.