rs397509428
A SNP in the ESR1 gene on chromosome 6. Its most notable genotype is G;T: Carrier for an estrogen resistance mutation
- Gene
- ESR1
- Location
- Chr 6152,011,684 (GRCh38)
- Highest magnitude
- 3.0Important
- Tested on
- AncestryDNA
Genotypes
As shown in 23andMe and AncestryDNA files.
- G;GGoodcommon in clinvar
- G;TMost notableBadCarrier for an estrogen resistance mutation
On SNPedia: (G;G), (G;T). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.
Related
Other ESR1 SNPs
- rs9340799G;GWomen have 10x risk of Endometriosis, but half the risk of Endometrial Cancer and 0.76x less cognitive impairment.Important
- rs104893956C;TCarrier for an estrogen resistance mutationImportant
- rs121913044A;TCarrier for an estrogen resistance mutationImportant
- rs2881766G;TSlightly increased risk for pregnancy-induced hypertensionMinor
- rs2295190T;TSlightly increased risk for ovarian cancer in womenMinor
- rs728524A;Acommon in complete genomicsTypical
- rs2179922A;Amales 1-2cm shorter on averageTypical
- rs2228480G;Gcommon in complete genomicsTypical
Notes
From SNPedia
Notes
see OMIM 133430.0006
G;T
Unaffected in absence of a second ESR1 gene mutation
Source and license
Adapted from rs397509428 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.
SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.