rs728524
A SNP in the ESR1 gene on chromosome 6. Its most notable genotype is A;A: common in complete genomics
- Gene
- ESR1
- Location
- Chr 6151,982,302 (GRCh38)
- Highest magnitude
- 0.0Typical
- Tested on
- 23andMe, AncestryDNA, FamilyTreeDNA
- Minor allele frequency
- 12%
Genotypes
As shown in 23andMe and AncestryDNA files.
On SNPedia: (A;A). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.
Frequency
Share of each genotype in 4 HapMap populations.
- AverageA;A 71%
- European ancestry (Utah)A;A 92%
- Han Chinese (Beijing)A;A 62%
- Japanese (Tokyo)A;A 68%
- Yoruba (Nigeria)A;A 61%
Related
Other ESR1 SNPs
- rs9340799G;GWomen have 10x risk of Endometriosis, but half the risk of Endometrial Cancer and 0.76x less cognitive impairment.Important
- rs104893956C;TCarrier for an estrogen resistance mutationImportant
- rs121913044A;TCarrier for an estrogen resistance mutationImportant
- rs397509428G;TCarrier for an estrogen resistance mutationImportant
- rs2881766G;TSlightly increased risk for pregnancy-induced hypertensionMinor
- rs2295190T;TSlightly increased risk for ovarian cancer in womenMinor
- rs2179922A;Amales 1-2cm shorter on averageTypical
- rs2228480G;Gcommon in complete genomicsTypical
Notes
From SNPedia
Notes
Among women rs8179176 rs9340799 rs1256065 and rs1256030 were associated with likelihood of developing cognitive impairment. In men, one of the rs728524 rs1255998 rs1256030 were associated with cognitive impairment.
Source and license
Adapted from rs728524 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.
SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.