rs2881766
A SNP in the ESR1 gene on chromosome 6. Its most notable genotype is G;T: Slightly increased risk for pregnancy-induced hypertension
- Gene
- ESR1
- Location
- Chr 6151,797,984 (GRCh38)
- Highest magnitude
- 1.5Minor
- Tested on
- 23andMe, AncestryDNA, FamilyTreeDNA
- Minor allele frequency
- 41%
Genotypes
As shown in 23andMe and AncestryDNA files.
- G;GGoodNormal risk for pregnancy-induced hypertension
- G;TMost notableBadSlightly increased risk for pregnancy-induced hypertension
- T;TBadSlightly increased risk for pregnancy-induced hypertension
On SNPedia: (G;G), (G;T), (T;T). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.
Frequency
Share of each genotype in 11 HapMap populations.
- AverageG;G 24% G;T 43% T;T 33%
- European ancestry (Utah)G;G 4% G;T 31% T;T 65%
- Han Chinese (Beijing)G;G 21% G;T 48% T;T 32%
- Japanese (Tokyo)G;G 18% G;T 55% T;T 28%
- Yoruba (Nigeria)G;G 49% G;T 43% T;T 8%
- African ancestry (Southwest US)G;G 35% G;T 51% T;T 14%
- Chinese (Denver)G;G 16% G;T 47% T;T 38%
- Gujarati IndianG;G 6% G;T 53% T;T 42%
- Luhya (Kenya)G;G 58% G;T 34% T;T 8%
- Mexican ancestry (Los Angeles)G;G 21% G;T 47% T;T 33%
- Maasai (Kenya)G;G 28% G;T 51% T;T 21%
- TuscanG;G 6% G;T 21% T;T 74%
Related
Other ESR1 SNPs
- rs9340799G;GWomen have 10x risk of Endometriosis, but half the risk of Endometrial Cancer and 0.76x less cognitive impairment.Important
- rs104893956C;TCarrier for an estrogen resistance mutationImportant
- rs121913044A;TCarrier for an estrogen resistance mutationImportant
- rs397509428G;TCarrier for an estrogen resistance mutationImportant
- rs2295190T;TSlightly increased risk for ovarian cancer in womenMinor
- rs728524A;Acommon in complete genomicsTypical
- rs2179922A;Amales 1-2cm shorter on averageTypical
- rs2228480G;Gcommon in complete genomicsTypical
Notes
From SNPedia
Notes
rs2881766 is a SNP in the promoter region of the estrogen receptor alpha ESR1 gene. Carriers of rs2881766(T) alleles are at somewhat (slightly) higher risk for pregnancy-induced hypertension.
Source and license
Adapted from rs2881766 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.
SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.