rs2285053

A SNP in the MMP2 gene on chromosome 16. Its most notable genotype is C;T: lower risk (by about 1/2) of lumbar disc disease (based on one 1 Chinese study)

Gene
MMP2
Location
Chr 1655,478,465 (GRCh38)
Highest magnitude
2.0Worth knowing
Tested on
23andMe
Minor allele frequency
17%

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. C;TMost notableGoodlower risk (by about 1/2) of lumbar disc disease (based on one 1 Chinese study)Worth knowing · 2.0
  2. T;TGoodlower risk (by about 1/2) of lumbar disc disease (based on one 1 Chinese study)Worth knowing · 2.0

On SNPedia: (C;T), (T;T). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Conditions, medicines and genes

Other MMP2 SNPs

All MMP2 SNPs

Notes

From SNPedia

Notes

rs2285053, also known as -735C>T, represents a variant in the promoter of the MMP2 gene on chromosome 16. A study of ~1000 Han Chinese patients with lumbar disc disease concluded that rs2285053(T) carriers were at lower risk for the disorder.

Source and license

Adapted from rs2285053 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.