rs267607924
A SNP in the MSH2 gene on chromosome 2. Its most notable genotype is A;G: Lynch syndrome
- Gene
- MSH2
- Location
- Chr 247,408,556 (GRCh38)
- Highest magnitude
- 6.0Very important
- Tested on
- 23andMe
Genotypes
As shown in 23andMe and AncestryDNA files.
- A;GMost notableBadLynch syndrome
- G;GGoodcommon in clinvar
- G;TBadLikely miscall in 23andMe data; otherwise, Lynch syndrome, pathogenic mutation
On SNPedia: (A;G), (G;G), (G;T). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.
Related
Conditions, medicines and genes
Other MSH2 SNPs
- rs63750245T;TLynch syndrome; hereditary nonpolyposis colorectal cancer-1Very important
- rs63750875C;CLynch syndrome; hereditary nonpolyposis colorectal cancer (HNPCC1)Very important
- rs63751449-;-Lynch syndrome; hereditary nonpolyposis colorectal cancer-1Very important
- rs12476364A;GLynch syndrome, pathogenic mutationVery important
- rs28929483C;TLynch syndrome, pathogenic mutationVery important
- rs28929484C;TLynch syndrome, pathogenic mutationVery important
- rs34986638G;TLynch syndrome, pathogenic mutationVery important
- rs63749802G;TLynch syndrome, pathogenic mutationVery important
Notes
From SNPedia
Notes
rs267607924, also known as c.366+1G>T and c.366+1G>A, is a variant in the MSH2 gene on chromosome 2. In ClinVar, the rs267607924(T) variant is rated pathogenic for Lynch syndrome by an expert panel, and the rs267607924(A) variant is considered pathogenic (or likely to be pathogenic) as well.
Source and license
Adapted from rs267607924 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.
SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.