rs267607944
A SNP in the MSH2 gene on chromosome 2. Its most notable genotype is C;G: Likely miscall in Ancestry data; otherwise, Lynch syndrome, pathogenic mutation
- Gene
- MSH2
- Location
- Chr 247,429,741 (GRCh38)
- Highest magnitude
- 6.0Very important
- Tested on
- AncestryDNA
Genotypes
As shown in 23andMe and AncestryDNA files.
- C;GMost notableBadLikely miscall in Ancestry data; otherwise, Lynch syndrome, pathogenic mutation
- G;GGoodcommon in clinvar
- G;TBadLynch syndrome, pathogenic mutation
On SNPedia: (C;G), (G;G), (G;T). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.
Related
Other MSH2 SNPs
- rs63750245T;TLynch syndrome; hereditary nonpolyposis colorectal cancer-1Very important
- rs63750875C;CLynch syndrome; hereditary nonpolyposis colorectal cancer (HNPCC1)Very important
- rs63751449-;-Lynch syndrome; hereditary nonpolyposis colorectal cancer-1Very important
- rs12476364A;GLynch syndrome, pathogenic mutationVery important
- rs28929483C;TLynch syndrome, pathogenic mutationVery important
- rs28929484C;TLynch syndrome, pathogenic mutationVery important
- rs34986638G;TLynch syndrome, pathogenic mutationVery important
- rs63749802G;TLynch syndrome, pathogenic mutationVery important
Notes
From SNPedia
Notes
aka c.1077-1G>C (or, c.1077-1G>T) Two ClinVar submitters assess c.1077-1G>C as pathogenic or likely to be pathogenic for Lynch Syndrome; the c.1077-1G>T mutation is assessed by one submitter as likely to be pathogenic.
Source and license
Adapted from rs267607944 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.
SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.