rs27072
A SNP in the SLC6A3 gene on chromosome 5. Its most notable genotype is C;C: 2x risk of severe alcohol withdrawal. Possible increased odds of ADHD.
- Gene
- SLC6A3
- Location
- Chr 51,394,407 (GRCh38)
- Highest magnitude
- 2.0Worth knowing
- Tested on
- 23andMe, AncestryDNA, FamilyTreeDNA
- Minor allele frequency
- 19%
Genotypes
As shown in 23andMe and AncestryDNA files.
- C;CMost notableBad2x risk of severe alcohol withdrawal. Possible increased odds of ADHD.
- C;TGoodLower risk of alcohol withdrawal seizures, and perhaps lower odds of ADHD.
- T;TGoodLower risk of alcohol withdrawal seizures, and probably lower odds of ADHD.
On SNPedia: (C;C), (C;T), (T;T). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.
Frequency
Share of each genotype in 11 HapMap populations.
- AverageC;C 69% C;T 28% T;T 3%
- European ancestry (Utah)C;C 68% C;T 29% T;T 4%
- Han Chinese (Beijing)C;C 52% C;T 40% T;T 8%
- Japanese (Tokyo)C;C 76% C;T 22% T;T 2%
- Yoruba (Nigeria)C;C 78% C;T 22% T;T 0%
- African ancestry (Southwest US)C;C 86% C;T 14% T;T 0%
- Chinese (Denver)C;C 61% C;T 34% T;T 5%
- Gujarati IndianC;C 54% C;T 39% T;T 8%
- Luhya (Kenya)C;C 72% C;T 27% T;T <1%
- Mexican ancestry (Los Angeles)C;C 71% C;T 29% T;T 0%
- Maasai (Kenya)C;C 78% C;T 21% T;T 2%
- TuscanC;C 68% C;T 29% T;T 3%
Related
Other SLC6A3 SNPs
- rs267607068T;TInfantile Parkinsonism-dystoniaVery important
- rs267607069A;AInfantile Parkinsonism-dystoniaVery important
- rs431905504T;TInfantile Parkinsonism-dystoniaVery important
- rs431905514T;TInfantile Parkinsonism-dystoniaVery important
- rs431905515G;GInfantile Parkinsonism-dystoniaVery important
- rs431905516A;AInfantile Parkinsonism-dystoniaVery important
- rs460000G;GBetter response to amphetamineWorth knowing
- rs464049G;Gdecreased risk of schizophrenia in limited studyMinor
Notes
From SNPedia
Show notes, about 390 words
rs27072, a SNP in the dopamine transporter SLC6A3 gene, has been associated with more severe symptoms upon alcohol withdrawal, such as seizures, in a study of 250 Caucasian alcohol-dependent patients. Two haplotypes appear to be tagged by this SNP and a neighbor, rs27048. The rs27072 polymorphism has been shown to be significantly associated with ADHD in clinical samples of Canadian children aged 6 to 16 [Feng et al., 2005] and the significant association was also reported by Ouellet-Morin et al. in a Canadian twin study, 2008 (Am. J. of Medical Genetics Part B, 147B:1442-1449 (2008). The interaction between the dopamine transporter gene and age at onset in relation to tobacco and alcohol use among 19-year-olds. Association of promoter variants of human dopamine transporter gene with schizophrenia in Han Chinese. Dopamine Transporter Gene Variant Affecting Expression in Human Brain is Associated with Bipolar Disorder. Sequence variation in the 3'-untranslated region of the dopamine transporter gene and attention-deficit hyperactivity disorder (ADHD). Association of the dopamine transporter gene and ADHD symptoms in a Canadian population-based sample of same-age twins. Candidate gene studies of ADHD: a meta-analytic review. Association between polymorphism of the dopamine transporter gene and early smoking onset: an interaction risk on nicotine dependence. Gene and gene by sex associations with initial sensitivity to nicotine in nonsmokers. Financial and psychological risk attitudes associated with two single nucleotide polymorphisms in the nicotine receptor (CHRNA4) gene. Haplotypes of dopamine and serotonin transporter genes are associated with antisocial personality disorder in alcoholics. Pharacogenetic effects of dopamine transporter gene polymorphisms on response to chlorpromazine and clozapine and on extrapyramidal syndrome in schizophrenia. The role of dopamine transporter (SLC6A3) and dopamine D2 receptor/ankyrin repeat and kinase domain containing 1 (DRD2/ANKK1) gene polymorphisms in personality traits. Alcohol Dependence
C;C
Alcoholics with this are twice as likely to have seizures during alcohol withdrawal.
C;T
Alcoholics with this are less likely to have seizures during alcohol withdrawal.
T;T
Alcoholics with this are less likely to have seizures during alcohol withdrawal.
Source and license
Adapted from rs27072 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.
SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.