rs431905516
A SNP in the SLC6A3 gene on chromosome 5. Its most notable genotype is A;A: Infantile Parkinsonism-dystonia
- Gene
- SLC6A3
- Location
- Chr 51,406,226 (GRCh38)
- Highest magnitude
- 8.0Very important
- Tested on
- AncestryDNA
Genotypes
Plus strand, as in 23andMe and AncestryDNA files.
- G;GGoodcommon in clinvar
- A;GBadCarrier of an infantile Parkinsonism-dystonia mutation
- A;AMost notableBadInfantile Parkinsonism-dystonia
SNPedia records rs431905516 on the minus strand: (C;C), (C;T), (T;T). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.
Related
Other SLC6A3 SNPs
- rs267607068T;TInfantile Parkinsonism-dystoniaVery important
- rs267607069A;AInfantile Parkinsonism-dystoniaVery important
- rs431905504T;TInfantile Parkinsonism-dystoniaVery important
- rs431905514T;TInfantile Parkinsonism-dystoniaVery important
- rs431905515G;GInfantile Parkinsonism-dystoniaVery important
- rs27072C;C2x risk of severe alcohol withdrawal. Possible increased odds of ADHD.Worth knowing
- rs460000G;GBetter response to amphetamineWorth knowing
- rs464049G;Gdecreased risk of schizophrenia in limited studyMinor
Notes
From SNPedia
Notes
c.1561C>T (p.Arg521Trp)
A;G
Unaffected in absence of a second SLC6A3 mutation; see SLC6A3
A;A
See SLC6A3
Source and license
Adapted from rs431905516 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.
SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.