rs460000

A SNP in the SLC6A3 gene on chromosome 5. Its most notable genotype is G;G: Better response to amphetamine

Gene
SLC6A3
Location
Chr 51,432,710 (GRCh38)
Highest magnitude
2.0Worth knowing
Tested on
23andMe, AncestryDNA, FamilyTreeDNA
Minor allele frequency
40%

Genotypes

Plus strand, as in 23andMe and AncestryDNA files.

  1. G;GMost notableNot ratedBetter response to amphetamineWorth knowing · 2.033% of people

SNPedia records rs460000 on the minus strand: (C;C). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 11 HapMap populations.

  • AverageG;G 33%
  • European ancestry (Utah)G;G 57%
  • Han Chinese (Beijing)G;G 19%
  • Japanese (Tokyo)G;G 14%
  • Yoruba (Nigeria)G;G 25%
  • African ancestry (Southwest US)G;G 30%
  • Chinese (Denver)G;G 19%
  • Gujarati IndianG;G 29%
  • Luhya (Kenya)G;G 20%
  • Mexican ancestry (Los Angeles)G;G 41%
  • Maasai (Kenya)G;G 49%
  • TuscanG;G 60%

Other SLC6A3 SNPs

All SLC6A3 SNPs

Notes

From SNPedia

Notes

G;G

Individuals with the C/C genotype at rs460000 (N = 83) reported approximately twofold higher ratings of stimulation and euphoria relative to the A/A+A/C (N = 69) genotype group, at both the 10 and 20 mg doses. PMID 20091113

References

Source and license

Adapted from rs460000 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.