rs28365083

A SNP in the CYP3A5 gene on chromosome 7. Its most notable genotype is T;T: CYP3A5*2 homozygote; nonexpressor for CYP3A5

Gene
CYP3A5
Location
Chr 799,652,613 (GRCh38)
Highest magnitude
2.5Worth knowing
Tested on
23andMe, AncestryDNA, FamilyTreeDNA
Minor allele frequency
<1%

Genotypes

Plus strand, as in 23andMe and AncestryDNA files.

  1. T;TMost notableBadCYP3A5*2 homozygote; nonexpressor for CYP3A5Worth knowing · 2.50% of people
  2. G;TNot ratedcarrier of one CYP3A5*2 alleleWorth knowing · 2.02% of people
  3. G;GGoodnormalTypical · 0.098% of people

SNPedia records rs28365083 on the minus strand: (A;A), (A;C), (C;C). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in one HapMap population.

  • European ancestry (Utah)T;T 0% G;T 2% G;G 98%

Other CYP3A5 SNPs

All CYP3A5 SNPs

Genosets

Genosets combine several genotypes. Twofold checks them in your report.

Notes

From SNPedia

Notes

rs28365083, also known as 27289C>A, is a SNP in the CYP3A5 gene. The rs28365083(A) allele defines the CYP3A5*2 variant, which is nonfunctional. Polymorphisms in the cytochrome P450 genes CYP1A2, CYP1B1, CYP3A4, CYP3A5, CYP11A1, CYP17A1, CYP19A1 and colorectal cancer risk. Genotyping panel for assessing response to cancer chemotherapy. Polymorphisms of drug-metabolizing enzymes (GST, CYP2B6 and CYP3A) affect the pharmacokinetics of thiotepa and tepa. Pazopanib-induced hyperbilirubinemia is associated with Gilbert's syndrome UGT1A1 polymorphism.

T;T

common for caucasians

Source and license

Adapted from rs28365083 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.