rs28365085

A SNP in the CYP3A5 gene on chromosome 7. Its most notable genotype is G;G: CYP3A5*3F homozygote; nonexpressor for CYP3A5

Gene
CYP3A5
Location
Chr 799,648,351 (GRCh38)
Highest magnitude
2.5Worth knowing
Tested on
Not on consumer chips
Minor allele frequency
<1%

Genotypes

Plus strand, as in 23andMe and AncestryDNA files.

  1. G;GMost notableBadCYP3A5*3F homozygote; nonexpressor for CYP3A5Worth knowing · 2.50% of people
  2. A;GNot ratedcarrier of one CYP3A5*3F alleleWorth knowing · 2.02% of people
  3. A;AGoodnormalTypical · 0.098% of people

SNPedia records rs28365085 on the minus strand: (C;C), (C;T), (T;T). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 3 HapMap populations.

  • AverageG;G 0% A;G 2% A;A 98%
  • Han Chinese (Beijing)G;G 0% A;G 2% A;A 99%
  • Japanese (Tokyo)G;G 0% A;G 4% A;A 96%
  • Chinese (Denver)G;G 0% A;G <1% A;A 99%

Other CYP3A5 SNPs

All CYP3A5 SNPs

Genosets

Genosets combine several genotypes. Twofold checks them in your report.

Notes

From SNPedia

Notes

rs45593941, also known as L82R, is a SNP in the CYP3A5 gene. The rs45593941(T) allele defines the CYP3A5*3F variant, which is nonfunctional.

Source and license

Adapted from rs28365085 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.