rs28383468

A SNP in the CYP3A5 gene on chromosome 7. Its most notable genotype is A;A: CYP3A5*H30Y homozygote; nonexpressor for CYP3A5

Gene
CYP3A5
Location
Chr 799,676,192 (GRCh38)
Highest magnitude
2.5Worth knowing
Tested on
23andMe
Minor allele frequency
<1%

Genotypes

Plus strand, as in 23andMe and AncestryDNA files.

  1. G;GGoodnormalTypical · 0.079% of people
  2. A;GNot ratedcarrier of one CYP3A5*H30Y alleleWorth knowing · 2.021% of people
  3. A;AMost notableBadCYP3A5*H30Y homozygote; nonexpressor for CYP3A5Worth knowing · 2.50% of people

SNPedia records rs28383468 on the minus strand: (C;C), (C;T), (T;T). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 2 HapMap populations.

  • AverageG;G 79% A;G 21% A;A 0%
  • Maasai (Kenya)G;G 60% A;G 40% A;A 0%
  • TuscanG;G 99% A;G 1% A;A 0%

Other CYP3A5 SNPs

All CYP3A5 SNPs

Genosets

Genosets combine several genotypes. Twofold checks them in your report.

Notes

From SNPedia

Notes

rs28383468, also known as 3705C>T or H30Y, is a SNP in the CYP3A5 gene. The rs28383468(T) allele defines the CYP3A5*H30Y variant, which is nonfunctional.

Source and license

Adapted from rs28383468 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.