rs41279854
A SNP in the CYP3A5 gene on chromosome 7. Its most notable genotype is G;G: CYP3A5*10 homozygote; nonexpressor for CYP3A5
- Gene
- CYP3A5
- Location
- Chr 799,650,149 (GRCh38)
- Highest magnitude
- 2.5Worth knowing
- Tested on
- 23andMe, AncestryDNA
Genotypes
As shown in 23andMe and AncestryDNA files.
- A;AGoodnormal
- A;GNot ratedcarrier of one CYP3A5*10 allele
- G;GMost notableBadCYP3A5*10 homozygote; nonexpressor for CYP3A5
On SNPedia: (A;A), (A;G), (G;G). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.
Related
Other CYP3A5 SNPs
- rs776746C;CCYP3A5*3 homozygote; CYP3A5 non-expressorWorth knowing
- rs10264272T;TCYP3A5*6 homozygote; nonexpressor for CYP3A5Worth knowing
- rs28365083T;TCYP3A5*2 homozygote; nonexpressor for CYP3A5Worth knowing
- rs28365085G;GCYP3A5*3F homozygote; nonexpressor for CYP3A5Worth knowing
- rs28383468A;ACYP3A5*H30Y homozygote; nonexpressor for CYP3A5Worth knowing
- rs28383479T;TCYP3A5*9 homozygote; nonexpressor for CYP3A5Worth knowing
- rs41279857T;TCYP3A5*S100Y homozygote; nonexpressor for CYP3A5Worth knowing
- rs41303343A;AMiscall in 23andMe v4 data; otherwise, CYP3A5*7 homozygote; nonexpressor for CYP3A5Worth knowing
Genosets
Genosets combine several genotypes. Twofold checks them in your report.
Notes
From SNPedia
Notes
rs41279854, also known as 29748T>C or F446S, is a SNP in the CYP3A5 gene. The rs41279854(G) allele defines the CYP3A5*10 variant, which is nonfunctional.
Source and license
Adapted from rs41279854 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.
SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.