rs28940579
A SNP in the MEFV gene on chromosome 16. Its most notable genotype is G;G: familial Mediterranean fever
- Gene
- MEFV
- Location
- Chr 163,243,310 (GRCh38)
- Highest magnitude
- 3.5Important
- Tested on
- 23andMe, AncestryDNA
- Minor allele frequency
- <1%
Genotypes
Plus strand, as in 23andMe and AncestryDNA files.
- G;GMost notableBadfamilial Mediterranean fever
- A;GBadCarrier of a familial mediterranean fever mutation
- A;AGoodcommon in clinvar
SNPedia records rs28940579 on the minus strand: (C;C), (C;T), (T;T). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.
Related
Conditions, medicines and genes
Other MEFV SNPs
- i4000404T;TFamilial Mediterranean FeverVery important
- i4000406C;Cfamilial mediterranean feverVery important
- i4000410T;Tfamilial mediterranean feverVery important
- rs28940580C;GFamilial mediterranean fever (predicted)Very important
- rs61732874A;Afamilial mediterranean feverVery important
- rs61752717C;Cfamilial mediterranean feverVery important
- rs104895093-;-Familial Mediterranean FeverVery important
- rs104895094C;CFamilial Mediterranean Fever, autosomal recessiveVery important
Notes
From SNPedia
Notes
rs28940579, also known as c.2177T>C, p.Val726Ala or V726A, is a SNP in the MEFV gene. The risk allele is given as (G) by 23andMe, however in dbSNP orientation, the risk allele is (C). The symptoms of familial Mediterranean fever are caused by the person's own inflammatory response; it is not an infectious disease. The condition is more common among Turks, Sephardic Jews, and people of Arab and Armenian ancestry.
A;G
Familial Mediterranean Fever mutation carrier; unaffected unless a second MEFV gene mutation is present.
Source and license
Adapted from rs28940579 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.
SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.