rs2981579
A SNP in the FGFR2 gene on chromosome 10. Its most notable genotype is G;G: common
- Gene
- FGFR2
- Location
- Chr 10121,577,821 (GRCh38)
- Highest magnitude
- 0.0Typical
- Tested on
- 23andMe, AncestryDNA
- Minor allele frequency
- 49%
Genotypes
Plus strand, as in 23andMe and AncestryDNA files.
- G;GMost notableNot ratedcommon
- A;GNot rated1.20x risk for breast cancer
- A;ANot rated1.64x risk for breast cancer
SNPedia records rs2981579 on the minus strand: (C;C), (C;T), (T;T). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.
Frequency
Share of each genotype in 11 HapMap populations.
- AverageG;G 26% A;G 47% A;A 27%
- European ancestry (Utah)G;G 35% A;G 38% A;A 27%
- Han Chinese (Beijing)G;G 33% A;G 45% A;A 22%
- Japanese (Tokyo)G;G 35% A;G 48% A;A 17%
- Yoruba (Nigeria)G;G 14% A;G 44% A;A 42%
- African ancestry (Southwest US)G;G 12% A;G 49% A;A 39%
- Chinese (Denver)G;G 36% A;G 47% A;A 17%
- Gujarati IndianG;G 31% A;G 54% A;A 16%
- Luhya (Kenya)G;G 14% A;G 50% A;A 36%
- Mexican ancestry (Los Angeles)G;G 29% A;G 50% A;A 21%
- Maasai (Kenya)G;G 16% A;G 46% A;A 39%
- TuscanG;G 27% A;G 48% A;A 26%
Related
Conditions, medicines and genes
Other FGFR2 SNPs
- rs2981582A;A1.7x higher risk of ER+ breast cancerImportant
- rs3750817T;T0.64x reduced risk for breast cancer, and higher likelihood of favorable postmenopausal hormone therapyWorth knowing
- rs1219648G;G1.64x risk for breast cancerWorth knowing
- rs2420946T;T1.64x risk for breast cancerWorth knowing
- rs4752566G;Tassociated with thicker hair in AsiansMinor
- rs755793A;Acommon in complete genomicsTypical
- rs1047100T;Tcommon in clinvarTypical
- rs2303568A;Acommon in complete genomicsTypical
Notes
From SNPedia
Show notes, about 150 words
This SNP is basically a proxy for SNP rs1219648, which represents the SNP in the FGFR2 gene with the strongest association with breast cancer. {Note: the alleles shown for this SNP in SNPedia are in orientation to the dbSNP entry, not as published.] Common variation in the fibroblast growth factor receptor 2 gene is not associated with endometriosis risk. Genome-wide association study provides evidence for a breast cancer risk locus at 6q22.33. Histone-acetylated control of fibroblast growth factor receptor 2 intron 2 polymorphisms and isoform splicing in breast cancer. Genetic variants in FGFR2 and FGFR4 genes and skin cancer risk in the Nurses' Health Study. FGFR2 and other loci identified in genome-wide association studies are associated with breast cancer in African-American and younger women. A genetic risk predictor for breast cancer using a combination of low-penetrance polymorphisms in a Japanese population.
Source and license
Adapted from rs2981579 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.
SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.