rs34983651
A SNP in the UGT1A10 gene on chromosome 2. Its most notable genotype is -;-: normal
- Gene
- UGT1A10
- Location
- Chr 2233,760,233 (GRCh38)
- Highest magnitude
- 0.0Typical
- Tested on
- 23andMe, AncestryDNA
Genotypes
As shown in 23andMe and AncestryDNA files.
- -;-Most notableNot ratednormal
- -;ATNot ratedsome effects of higher bilirubin
- AT;ATNot ratedeffects of higher bilirubin; irinotecan toxicity
On SNPedia: (-;-), (-;AT), (AT;AT). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.
Related
Conditions, medicines and genes
Other UGT1A10 SNPs
- rs6742078T;T+16% bilirubin levels increased risk of gallstonesWorth knowing
- rs887829T;THigher levels of serum bilirubin, associated with lower risk for coronary artery diseaseWorth knowing
- rs3755319C;Cmost likely a benign polymorphismMinor
- rs11892031A;ANo summary available.Typical
- rs34815109-;-normalTypical
Notes
From SNPedia
Show notes, about 130 words
rs34983651 is one of four SNPs all describing an insertion/deletion polymorphism in the promoter region of the UGT1A1 gene; the primary entry in SNPedia for this set of SNPs is at rs34815109. Futhermore, several of these SNPs now have been merged by dbSNP to rs3064744. The other two SNPs (besides rs34815109) that also describe the same polymorphism are: * rs35600288 * rs5839491 Note: DNA testing companies reporting genotypes as "II", "DI" or "DD" for this SNP may vary in how they define those terms for this SNP. In general, based on Promethease user data, it appears as if Ancestry's v2c and v2d chips interpret the normal allele as "D", whereas 23andMe v2-v4 chips interpret it as "I". These chips (v2-v4) appear to have false negatives for this SNP, and this SNP is not reported on the v5 chip.
Source and license
Adapted from rs34983651 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.
SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.