rs6742078

A SNP in the UGT1A10 gene on chromosome 2. Its most notable genotype is T;T: +16% bilirubin levels increased risk of gallstones

Gene
UGT1A10
Location
Chr 2233,763,993 (GRCh38)
Highest magnitude
2.1Worth knowing
Tested on
23andMe, AncestryDNA
Minor allele frequency
30%

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. G;GGoodnormalTypical · 0.045% of people
  2. G;TNot ratedNo summary available.Typical · 0.043% of people
  3. T;TMost notableBad+16% bilirubin levels increased risk of gallstonesWorth knowing · 2.112% of people

On SNPedia: (G;G), (G;T), (T;T). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 11 HapMap populations.

  • AverageG;G 45% G;T 43% T;T 12%
  • European ancestry (Utah)G;G 45% G;T 47% T;T 8%
  • Han Chinese (Beijing)G;G 76% G;T 23% T;T 2%
  • Japanese (Tokyo)G;G 71% G;T 24% T;T 5%
  • Yoruba (Nigeria)G;G 29% G;T 48% T;T 23%
  • African ancestry (Southwest US)G;G 23% G;T 63% T;T 14%
  • Chinese (Denver)G;G 72% G;T 26% T;T 2%
  • Gujarati IndianG;G 35% G;T 44% T;T 22%
  • Luhya (Kenya)G;G 22% G;T 62% T;T 16%
  • Mexican ancestry (Los Angeles)G;G 45% G;T 48% T;T 7%
  • Maasai (Kenya)G;G 28% G;T 50% T;T 23%
  • TuscanG;G 51% G;T 40% T;T 9%

Conditions, medicines and genes

Other UGT1A10 SNPs

All UGT1A10 SNPs

Notes

From SNPedia

Notes

Xenobiotic metabolizing gene variants, dietary heterocyclic amine intake, and risk of prostate cancer. Serum bilirubin levels on ICU admission are associated with ARDS development and mortality in sepsis.

Source and license

Adapted from rs6742078 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.