rs3755319

A SNP in the UGT1A10 gene on chromosome 2. Its most notable genotype is C;C: most likely a benign polymorphism

Gene
UGT1A10
Location
Chr 2233,758,936 (GRCh38)
Highest magnitude
1.0Minor
Tested on
23andMe, AncestryDNA, FamilyTreeDNA

Genotypes

Plus strand, as in 23andMe and AncestryDNA files.

  1. C;CMost notableGoodmost likely a benign polymorphismMinor · 1.030% of people
  2. A;CGoodmost likely a benign polymorphismMinor · 1.046% of people
  3. A;AGoodcommon in clinvarTypical · 0.024% of people

SNPedia records rs3755319 on the minus strand: (G;G), (G;T), (T;T). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 11 HapMap populations.

  • AverageC;C 30% A;C 46% A;A 24%
  • European ancestry (Utah)C;C 21% A;C 48% A;A 30%
  • Han Chinese (Beijing)C;C 7% A;C 47% A;A 46%
  • Japanese (Tokyo)C;C 10% A;C 42% A;A 49%
  • Yoruba (Nigeria)C;C 54% A;C 40% A;A 6%
  • African ancestry (Southwest US)C;C 35% A;C 58% A;A 7%
  • Chinese (Denver)C;C 8% A;C 46% A;A 45%
  • Gujarati IndianC;C 33% A;C 55% A;A 12%
  • Luhya (Kenya)C;C 56% A;C 40% A;A 4%
  • Mexican ancestry (Los Angeles)C;C 28% A;C 43% A;A 29%
  • Maasai (Kenya)C;C 55% A;C 36% A;A 9%
  • TuscanC;C 20% A;C 51% A;A 29%

Other UGT1A10 SNPs

All UGT1A10 SNPs

Notes

From SNPedia

Notes

aka c.-1352A= (and probably also c.-1353A=) The "A" variant (T in dbSNP orientation) has been observed in a few Japanese newborns with hyperbilirubinemia, but the association is hardly causative, and even the authors conclude the pathogenicity is "uncertain".

Source and license

Adapted from rs3755319 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.