rs363043

A SNP in the SNAP25 gene on chromosome 20. Its most notable genotype is C;C.

Gene
SNAP25
Location
Chr 2010,245,498 (GRCh38)
Highest magnitude
0.0Typical
Tested on
23andMe, AncestryDNA, FamilyTreeDNA
Minor allele frequency
23%

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. C;CMost notableNot ratedNo summary available.Typical · 0.062% of people
  2. C;TNot ratedNo summary available.Typical · 0.030% of people
  3. T;TNot ratedNo summary available.Typical · 0.08% of people

On SNPedia: (C;C), (C;T), (T;T). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 11 HapMap populations.

  • AverageC;C 62% C;T 30% T;T 8%
  • European ancestry (Utah)C;C 50% C;T 42% T;T 9%
  • Han Chinese (Beijing)C;C 99% C;T <1% T;T 0%
  • Japanese (Tokyo)C;C 99% C;T <1% T;T 0%
  • Yoruba (Nigeria)C;C 36% C;T 49% T;T 15%
  • African ancestry (Southwest US)C;C 35% C;T 49% T;T 16%
  • Chinese (Denver)C;C 99% C;T <1% T;T 0%
  • Gujarati IndianC;C 65% C;T 32% T;T 3%
  • Luhya (Kenya)C;C 45% C;T 42% T;T 14%
  • Mexican ancestry (Los Angeles)C;C 72% C;T 24% T;T 3%
  • Maasai (Kenya)C;C 30% C;T 55% T;T 15%
  • TuscanC;C 49% C;T 41% T;T 10%

Other SNAP25 SNPs

All SNAP25 SNPs

Notes

From SNPedia

Notes

SNPs in the SNAP25 gene were initially linked to intelligence but have failed to replicate . While now suspect, the original work can be found in . The (T;T) genotype averages several PIQ points higher than the (C;T) genotype, which averages several PIQ points higher than the (C;C) genotype. For SNPs rs363039 - rs363043 - rs353016, respectively, the haplotype C-T-T is most associated with higher intelligence in children, whereas the haplotype C-C-T is most associated in adults (SNPs oriented as in dbSNP).

Source and license

Adapted from rs363043 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.