rs363050
A SNP in the SNAP25 gene on chromosome 20. Its most notable genotype is A;A.
- Gene
- SNAP25
- Location
- Chr 2010,253,609 (GRCh38)
- Highest magnitude
- 1.1Minor
- Tested on
- 23andMe, AncestryDNA
- Minor allele frequency
- 47%
Genotypes
As shown in 23andMe and AncestryDNA files.
- A;AMost notableGoodNo summary available.
- A;GNot ratedNo summary available.
- G;GBadNo summary available.
On SNPedia: (A;A), (A;G), (G;G). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.
Frequency
Share of each genotype in 11 HapMap populations.
- AverageA;A 25% A;G 47% G;G 28%
- European ancestry (Utah)A;A 29% A;G 46% G;G 25%
- Han Chinese (Beijing)A;A 7% A;G 45% G;G 48%
- Japanese (Tokyo)A;A 3% A;G 47% G;G 50%
- Yoruba (Nigeria)A;A 33% A;G 57% G;G 10%
- African ancestry (Southwest US)A;A 42% A;G 42% G;G 16%
- Chinese (Denver)A;A 11% A;G 39% G;G 51%
- Gujarati IndianA;A 29% A;G 48% G;G 24%
- Luhya (Kenya)A;A 38% A;G 39% G;G 24%
- Mexican ancestry (Los Angeles)A;A 10% A;G 59% G;G 31%
- Maasai (Kenya)A;A 39% A;G 50% G;G 11%
- TuscanA;A 35% A;G 44% G;G 21%
Related
Notes
From SNPedia
Show notes, about 190 words
SNPs in the SNAP25 gene were initially linked to intelligence but have failed to replicate . While now suspect, the original work can be found in . The (A;A) genotype averaged 2.84 PIQ points higher than the (A;G) genotype, which averages 2.8 PIQ points higher than the (G;G) genotype (p=0.0002). Variance in this SNP may account for 3.4% of the phenotypic variance in PIQ. rs363050 is in close linkage with rs353016, with r2 = 0.98, such that the rs363050(A) allele typically is linked to the rs353016(T) allele. For SNPs rs363039 - rs363043 - rs353016, respectively, the haplotype C-T-T is most associated with higher intelligence in children, whereas the haplotype C-C-T is most associated in adults (SNPs oriented as in dbSNP). Measures of Intelligence
A;A
The (A;A) genotype averaged 2.84 PIQ points higher than the (A;G) genotype, which averages 2.8 PIQ points higher than the (G;G)
A;G
The (A;G) genotype averages 2.8 PIQ points higher than the (G;G), but averages 2.84 PIQ points lower than (A;A) genotype
G;G
The (G;G) genotype averages 2.84 PIQ points lower than (A;A) genotype and averages 2.8 PIQ points lower than (A;G) genotype
Source and license
Adapted from rs363050 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.
SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.