rs3746544

A SNP in the SNAP25 gene on chromosome 20. Its most notable genotype is T;T: Associated with ADHD

Gene
SNAP25
Location
Chr 2010,306,436 (GRCh38)
Highest magnitude
0.0Typical
Tested on
23andMe, AncestryDNA, FamilyTreeDNA
Minor allele frequency
29%

Genotypes

Plus strand, as in 23andMe and AncestryDNA files.

  1. T;TMost notableBadAssociated with ADHDTypical · 0.052% of people
  2. G;GBadAssociated with SchizophreniaTypical · 0.07% of people

SNPedia records rs3746544 on the minus strand: (A;A), (C;C). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 11 HapMap populations.

  • AverageT;T 52% G;G 7%
  • European ancestry (Utah)T;T 39% G;G 15%
  • Han Chinese (Beijing)T;T 63% G;G 4%
  • Japanese (Tokyo)T;T 44% G;G 8%
  • Yoruba (Nigeria)T;T 51% G;G 7%
  • African ancestry (Southwest US)T;T 63% G;G 4%
  • Chinese (Denver)T;T 60% G;G 6%
  • Gujarati IndianT;T 55% G;G 8%
  • Luhya (Kenya)T;T 46% G;G 6%
  • Mexican ancestry (Los Angeles)T;T 55% G;G 2%
  • Maasai (Kenya)T;T 51% G;G 7%
  • TuscanT;T 43% G;G 8%

Conditions, medicines and genes

Other SNAP25 SNPs

All SNAP25 SNPs

Notes

From SNPedia

Show notes, about 130 words

SNPs nominally associated with schizophrenia (rs3787283, rs3746544) were the same as those previously demonstrated to be associated with ADHD but with the opposite alleles, allowing the intriguing hypothesis that genetic variation at SNAP25 may be differentially associated with both schizophrenia and ADHD When comparing pooled results of multiple ADHD studies, only rs3746544(A) was found to have a significant association (p=0.028) with slightly increased risk (OR 1.15 at 95%) of ADHD. Support for the MnlI polymorphism of SNAP25; a Korean ADHD case-control study. Investigation of variation in SNAP-25 and ADHD and relationship to co-morbid major depressive disorder. Biased paternal transmission of SNAP-25 risk alleles in attention-deficit hyperactivity disorder.

Source and license

Adapted from rs3746544 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.