rs3736228

A SNP in the LRP5 gene on chromosome 11. Its most notable genotype is T;T: increased risk for osteoporosis

Gene
LRP5
Location
Chr 1168,433,827 (GRCh38)
Highest magnitude
1.7Minor
Tested on
23andMe, AncestryDNA
Minor allele frequency
14%

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. C;CGoodnormalTypical · 0.077% of people
  2. C;TBadincreased risk for osteoporosisMinor · 1.321% of people
  3. T;TMost notableBadincreased risk for osteoporosisMinor · 1.72% of people

On SNPedia: (C;C), (C;T), (T;T). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 11 HapMap populations.

  • AverageC;C 77% C;T 21% T;T 2%
  • European ancestry (Utah)C;C 74% C;T 24% T;T 2%
  • Han Chinese (Beijing)C;C 67% C;T 31% T;T 2%
  • Japanese (Tokyo)C;C 50% C;T 44% T;T 5%
  • Yoruba (Nigeria)C;C 97% C;T 3% T;T 0%
  • African ancestry (Southwest US)C;C 91% C;T 7% T;T 2%
  • Chinese (Denver)C;C 61% C;T 36% T;T 4%
  • Gujarati IndianC;C 79% C;T 21% T;T 0%
  • Luhya (Kenya)C;C 96% C;T 4% T;T 0%
  • Mexican ancestry (Los Angeles)C;C 63% C;T 35% T;T 2%
  • Maasai (Kenya)C;C 89% C;T 11% T;T <1%
  • TuscanC;C 79% C;T 20% T;T 1%

Other LRP5 SNPs

All LRP5 SNPs

Notes

From SNPedia

Show notes, about 370 words

rs3736228 is a SNP in the LRP5 gene that is also known as Ala1330Val or A1330V; the more common (C) allele encodes the Ala (alanine), while the rarer (T) allele encodes the Val (valine), which is the risk allele. rs3736228(T) is associated with vertebral fractures and reduced bone mineral density (BMD), with an overall odds ratio for fractures of 1.06 per allele (CI: 1.01-1.12; 7802 fractures among 31,199 individuals studied). More specifically, the rs3736228(T) allele was associated with reduced lumbar spine BMD (p = 2.6 x 10 -9 ), and femoral neck BMD (p = 5.0 x 10 -6 ). Note that rs4988321, another LRP5 SNP (also known as Val667Met), was independently associated with BMD in this same study. news rs3736228 was associated with a 30% increase in the risk of both osteoporosis and osteoporotic fractures. Both increases were significant, at P=0.002 and P=0.008, respectively. rs3736228 associated with decreased bone mineral density (p=6.3x10(-12) for lumbar spine and p=1.9x10(-4) for femoral neck) and an increased risk of both osteoporotic fractures (odds ratio [OR] 1.3, 95% CI 1.09-1.52, p=0.002) and osteoporosis (OR 1.3, 1.08-1.63, p=0.008). rs4355801 associated with decreased bone mineral density (p=7.6x10(-10) for lumbar spine and p=3.3x10(-8) for femoral neck) and increased risk of osteoporosis (OR 1.2, 95% CI 1.01-1.42, p=0.038). The presence of both risk alleles increased the risk of osteoporotic fractures (OR 1.3, 1.08-1.63, p=0.006) and this effect was independent of bone mineral density. A later study (2009) also found an association between rs3736228 and hip BMD; subjects with rs3736228(T;T) genotypes had 8.4% higher total-hip BMD compared to other genotypes (p = 0.009) at baseline in a study of 249 osteoporotic Caucasian men.

C;T

Carried by 21% of people with European ancestry, this genotype has one copy of the higher risk variant (T), which leads to being 1.33 times as likely to develop osteoporosis as someone with no (T) variants for this SNP.

T;T

Carried by 2% of people with European ancestry, this genotype has two copies of the higher risk variant (T), which leads to being 1.66 times as likely to develop osteoporosis as someone with no (T) variants for this SNP.

Source and license

Adapted from rs3736228 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.